Pigment granule maturation

Across TCGA cell cohorts, RNA activity of the Pigment granule maturation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTRF1L, MICAL2, and DKK3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTRF1L grouped by Pigment granule maturation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MTRF1L →	-0.457	-0.906	.002	.007	3	5
OVARY	MICAL2 →	-1.604	-0.896	<.001	.004	3	4
OVARY	DKK3 →	-2.845	-1.622	.003	<.001	3	4
BREAST	KIAA0753 →	-0.674	-0.961	.006	.001	3	4
LUNG_NSCLC_LUSC	MBD6 →	+0.717	+1.427	.002	<.001	3	4
BLOOD_Myeloma	RECQL →	-0.726	-1.284	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTRF1L by Pigment granule maturation activity — CNS

Explore this box plot interactively →