Branching morphogenesis of an epithelial tube

Across TCGA patient cohorts, RNA activity of the Branching morphogenesis of an epithelial tube pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASGRF2, PCDH12, and DHH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Branching morphogenesis of an epithelial tube activity versus RASGRF2 in CCRCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RASGRF2 →	+0.754	+0.594	.002	.001	3	5
CCRCC	PCDH12 →	+0.849	+0.610	<.001	<.001	3	5
BRCA	DHH →	+0.146	+0.349	.009	.001	3	5
OV	CRTC3 →	+0.719	+0.472	.005	.009	3	5
BRCA	HTR7P1 →	+0.904	+0.340	<.001	<.001	3	5
CCRCC	NOTCH4 →	+0.913	+0.623	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048754 vs RASGRF2 — CCRCC

Explore this scatter interactively →