Embryonic viscerocranium morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic viscerocranium morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHST11, HOXA2, and MTHFD1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHST11 grouped by Embryonic viscerocranium morphogenesis-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CHST11 →	-0.284	-1.293	<.001	<.001	3	8
LUNG_SCLC	HOXA2 →	-0.160	-0.305	.008	.003	3	5
LARGE_INTESTINE	MTHFD1 →	-0.452	-0.677	<.001	.005	3	4
LIVER	POLR2A →	+0.451	+1.930	.009	.001	3	4
OVARY	IRF1 →	-0.185	-0.756	.006	.007	3	3
OVARY	ZNF185 →	+0.171	+0.894	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHST11 by Embryonic viscerocranium morphogenesis activity — OVARY

Explore this box plot interactively →