Embryonic viscerocranium morphogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Embryonic viscerocranium morphogenesis pathway differs between tumor and matched normal tissue in 15 of the 18 cancer types tested.

The strongest signal is observed in thyroid carcinoma (THCA), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KICH, show the opposite pattern, with lower activity in tumor tissue.

THCA, COAD, and BLCA show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
THCA	All	III,IV	+0.066	<.001	10	view →
COAD	Female	II,III,IV	+0.061	<.001	10	view →
BLCA	Male	III,IV	+0.140	<.001	9	view →
HNSC	Male	III,IV	+0.077	<.001	9	view →
KIRC	Male	All	+0.076	<.001	9	view →
LUAD	Male	All	+0.093	<.001	8	view →
STAD	All	II,III,IV	+0.087	<.001	8	view →
LUSC	Male	II,III,IV	+0.097	<.001	7	view →
KIRP	All	All	+0.045	<.001	7	view →
UCEC	All	II,III,IV	+0.127	<.001	6	view →
READ	All	III,IV	+0.074	.004	6	view →
BRCA	All	All	+0.027	<.001	4	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 15 lineages.

GO:0048703–THCA

Open the THCA breakdown →