Embryonic viscerocranium morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic viscerocranium morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TF, ZNF141, and SETD4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TF grouped by Embryonic viscerocranium morphogenesis-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TF →	+0.301	+0.206	.003	.002	3	4
LUNG_NSCLC_LUSC	ZNF141 →	-0.186	-0.129	.001	<.001	3	4
OESOPHAGUS	SETD4 →	-0.252	-0.266	.009	.003	3	4
BLOOD_Myeloma	ACTG1 →	+0.343	+0.123	.003	.007	3	4
KIDNEY	RHOG →	-0.307	-0.121	.007	.005	3	4
PANCREAS	PROX1 →	+0.228	+0.146	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TF by Embryonic viscerocranium morphogenesis activity — PANCREAS

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