Embryonic digestive tract morphogenesis

Across TCGA patient cohorts, RNA activity of the Embryonic digestive tract morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF559, ZFP14, and ZNF891, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic digestive tract morphogenesis activity versus ZNF559 in GBM (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ZNF559 →	+0.392	+0.807	<.001	<.001	3	7
GBM	ZFP14 →	+0.418	+0.949	.001	<.001	3	6
CCRCC	ZNF891 →	+0.339	+0.667	<.001	<.001	3	6
LSCC	RPL23AP52 →	+0.458	+0.638	.001	.002	3	5
BRCA	ZNF594 →	+0.717	+0.823	<.001	<.001	3	5
BRCA	ZNF287 →	+0.388	+0.587	.006	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048557 vs ZNF559 — GBM

Explore this scatter interactively →