Q-omics provides the consensus-scored ZNF891 profile across patient tissues and cancer cell-line models. ZNF891 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in UCS. Among the 18 cancer types available for tumor–normal comparison, ZNF891 is differentially expressed in 10, with the highest sampling consensus in THCA. Additionally, ZNF891 RNA expression shows 21,663 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UCS, THCA, and UVM as cancer lineages where ZNF891 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ZNF891 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ZNF891 survival associations across molecular data types. ZNF891 RNA expression shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ZNF891 RNA expression–survival associations across cancer types. High ZNF891 expression shows unfavorable associations in UVM and ACC, but favorable associations in UCS, HNSC, READ and GBM. The UCS Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify UCS as the clearest survival context for ZNF891 RNA expression.
This table summarizes ZNF891 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for ZNF891. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ZNF891 shows lower tumor expression in THCA and KICH and higher tumor expression in LIHC, LUAD, CHOL and COAD. The THCA box plot shows higher ZNF891 RNA expression in normal versus tumor tissue (log2 FC = −0.614, t-test p < 0.001).
This table shows molecular features associated with ZNF891 in patient tissues and cancer cell lines. In patient samples, ZNF891 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, ZNF891 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OVARY, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and BLOOD_Leukemia.
