Embryonic digestive tract morphogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Embryonic digestive tract morphogenesis pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 17 member genes.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher Embryonic digestive tract morphogenesis pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as CESC and UCEC, show the opposite pattern, with higher activity associated with better survival.

CESC, UCEC, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	II,III,IV	0.913	0.629	<.001	66	view →
UCEC	DFS	Median	All	0.893	0.784	<.001	62	view →
LGG	OS	Tertile	All	0.697	0.869	<.001	37	view →
LAML	DFS	Median	All	0.289	0.477	.009	30	view →
ACC	DFS	Median	All	0.161	0.711	<.001	23	view →
LUAD	OS	Quartile	All	0.904	0.767	.005	22	view →
OV	OS	Median	IV	0.773	0.501	.003	20	view →
SCLC	OS	Median	All	0.584	1.000	.005	17	view →
DLBC	OS	Median	All	1.000	0.576	.021	16	view →
BRCA	DFS	Median	III,IV	0.831	0.912	.003	14	view →
SKCM	OS	Quartile	IV	0.955	0.360	.010	14	view →
LIHC	OS	Quartile	All	0.790	0.451	.006	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0048557–CESC (OS)

Open the CESC breakdown →