Acid secretion

Across TCGA patient cohorts, RNA activity of the Acid secretion pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAPRIN1, LRP1, and MCM2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acid secretion activity versus CAPRIN1 in BRCA (Pearson r = 0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CAPRIN1 →	-0.256	-0.025	.008	.004	2	9
BRCA	LRP1 →	+0.457	+0.029	.001	<.001	3	8
GBM	MCM2 →	-0.664	-0.054	<.001	<.001	3	8
CCRCC	GGT5 →	+0.546	+0.038	.001	.002	3	8
GBM	RFC1_S368 →	-0.759	-0.051	<.001	<.001	3	8
GBM	MCM7 →	-0.737	-0.050	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046717 vs CAPRIN1 — BRCA

Explore this scatter interactively →