Regulation of insulin receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of insulin receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HYI, PRKCQ_T538, and RPL5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of insulin receptor signaling pathway activity versus HYI in BRCA (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HYI →	+0.546	+0.037	<.001	<.001	3	8
UCEC	PRKCQ_T538 →	+1.476	+0.051	<.001	<.001	3	8
BRCA	RPL5 →	-0.217	-0.035	<.001	<.001	3	8
BRCA	CNRIP1 →	+0.612	+0.036	<.001	<.001	3	8
BRCA	ESD →	+0.351	+0.032	.001	.002	3	8
LSCC	CLPX →	-0.329	-0.046	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046626 vs HYI — BRCA

Explore this scatter interactively →