Regulation of insulin receptor signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of insulin receptor signaling pathway pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 69 member genes.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher Regulation of insulin receptor signaling pathway pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUAD and BRCA, show the opposite pattern, with higher activity associated with better survival.

LUAD, BRCA, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.764	0.593	<.001	127	view →
BRCA	OS	Quartile	All	0.985	0.943	<.001	50	view →
KIRC	DFS	Median	III,IV	0.346	0.584	<.001	44	view →
SKCM	OS	Median	III,IV	0.555	0.269	.005	33	view →
COAD	DFS	Tertile	III,IV	0.715	0.466	.001	32	view →
ACC	DFS	Quartile	II,III,IV	0.380	0.769	.001	24	view →
ESCA	OS	Median	III,IV	0.614	0.341	.022	21	view →
CHOL	DFS	Tertile	All	0.747	0.199	.006	20	view →
HNSC	DFS	Median	III,IV	0.483	0.722	.007	13	view →
UCS	OS	Median	III,IV	0.576	0.214	.008	12	view →
SCLC	DFS	Tertile	All	0.490	0.158	.019	8	view →
KIRP	DFS	Quartile	All	0.601	0.784	.027	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0046626–LUAD (DFS)

Open the LUAD breakdown →