Regulation of insulin receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of insulin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEAD3, SLC9A2, and RPS7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TEAD3 grouped by Regulation of insulin receptor signaling pathway-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TEAD3 →	+1.966	+0.207	.002	.002	3	5
URINARY_TRACT	SLC9A2 →	+1.699	+0.346	.002	.008	3	4
LIVER	RPS7 →	-0.802	-0.308	.006	.002	3	4
LUNG_NSCLC_LUAD	CDC123 →	-0.853	-0.161	<.001	<.001	3	4
STOMACH	RAD9A →	+0.731	+0.159	.002	.005	3	4
CNS	FAM117B →	+0.840	+0.156	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TEAD3 by Regulation of insulin receptor signaling pathway activity — LUNG_SCLC

Explore this box plot interactively →