Short-chain fatty acid metabolic process

Across TCGA cell cohorts, RNA activity of the Short-chain fatty acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLYBL, NDUFAF4, and LDLRAP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLYBL grouped by Short-chain fatty acid metabolic process-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CLYBL →	-1.268	-1.260	<.001	.008	3	4
SKIN	NDUFAF4 →	-0.910	-1.387	.001	<.001	3	4
LARGE_INTESTINE	LDLRAP1 →	-0.867	-1.317	<.001	<.001	3	4
PANCREAS	LY6K →	+2.386	+1.327	.001	<.001	3	4
PANCREAS	FOXC2 →	+1.721	+1.388	.001	<.001	3	4
BONE	RUBCNL →	-3.411	-1.231	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLYBL by Short-chain fatty acid metabolic process activity — BONE

Explore this box plot interactively →