Negative regulation of osteoblast differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of osteoblast differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DAB2, PDS5A_T1208, and FANCD2_S1435, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of osteoblast differentiation activity versus DAB2 in OV (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DAB2 →	+0.331	+0.038	.005	.004	3	8
BRCA	PDS5A_T1208 →	-0.697	-0.030	<.001	.001	3	7
BRCA	FANCD2_S1435 →	-1.067	-0.035	<.001	<.001	3	6
UCEC	BAZ1B_S349 →	-0.648	-0.045	.002	.004	3	6
UCEC	CNPY4 →	+0.525	+0.059	<.001	<.001	3	6
OV	EZH2_T367 →	-1.429	-0.044	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045668 vs DAB2 — OV

Explore this scatter interactively →