Negative regulation of osteoblast differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of osteoblast differentiation pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 58 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Negative regulation of osteoblast differentiation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and SKCM, show the opposite pattern, with higher activity associated with better survival.

LGG, BRCA, and SKCM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.349	0.517	<.001	48	view →
BRCA	OS	Tertile	III,IV	0.925	0.761	.001	38	view →
SKCM	OS	Quartile	II,III,IV	0.845	0.648	.002	31	view →
KIRC	DFS	Quartile	IV	0.345	0.750	.003	26	view →
CESC	DFS	Quartile	All	0.741	0.914	.001	20	view →
ESCA	DFS	Quartile	III,IV	0.602	0.246	.007	20	view →
THCA	OS	Tertile	All	0.939	1.000	.005	20	view →
BLCA	DFS	Tertile	All	0.691	0.559	.010	18	view →
STAD	OS	Tertile	All	0.632	0.850	.014	15	view →
GBM	OS	Quartile	All	0.314	0.514	.013	12	view →
PRAD	OS	Median	All	0.931	0.791	.020	8	view →
TGCT	DFS	Median	All	0.760	0.903	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0045668–LGG (OS)

Open the LGG breakdown →