Negative regulation of osteoblast differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of osteoblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AEBP1, MRC2, and CNRIP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of osteoblast differentiation activity versus AEBP1 in OV (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	AEBP1 →	+2.031	+0.851	<.001	.003	3	5
GBM	MRC2 →	+0.474	+0.548	.003	.006	3	5
BRCA	CNRIP1 →	+0.607	+0.385	.002	.006	3	5
OV	COL6A3 →	+1.313	+0.686	.001	.009	3	5
GBM	EFEMP2 →	+0.643	+0.755	<.001	.001	3	5
GBM	CAVIN1 →	+0.688	+0.688	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045668 vs AEBP1 — OV

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