Negative regulation of osteoblast differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of osteoblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDHD1, MKNK1, and PPP1R15A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of osteoblast differentiation activity versus WDHD1 in BLOOD_Leukemia (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	WDHD1 →	+0.776	+0.869	<.001	<.001	3	5
LUNG_NSCLC_LUSC	MKNK1 →	-1.117	-1.524	.003	.008	3	4
BLOOD_Leukemia	PPP1R15A →	-1.327	-0.738	.001	.001	3	4
PANCREAS	GINS1 →	+0.827	+1.132	.007	.002	3	4
PANCREAS	PPP6C →	+0.705	+1.310	.004	<.001	3	4
LUNG_NSCLC_LUAD	TRIOBP →	-0.509	-0.608	.008	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045668 vs WDHD1 — BLOOD_Leukemia

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