Cell cycle G2/M phase transition

Across TCGA patient cohorts, RNA activity of the Cell cycle G2/M phase transition pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A, RRM2, and SETDB1_S1066, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell cycle G2/M phase transition activity versus TOP2A in LUAD (Pearson r = 0.74).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TOP2A →	+1.211	+0.080	<.001	<.001	3	10
LUAD	RRM2 →	+0.975	+0.078	<.001	<.001	3	9
LUAD	SETDB1_S1066 →	+0.958	+0.077	<.001	<.001	3	9
UCEC	SMC2 →	+0.738	+0.087	<.001	<.001	3	9
LUAD	SMC4 →	+0.706	+0.080	<.001	<.001	3	9
LUAD	TACC3_S71 →	+1.320	+0.068	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044839 vs TOP2A — LUAD

Explore this scatter interactively →