Protein K27-linked ubiquitination

Across TCGA patient cohorts, RNA activity of the Protein K27-linked ubiquitination pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCAPG_S674, RFC2, and RFC3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein K27-linked ubiquitination activity versus NCAPG_S674 in OV (Pearson r = -0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NCAPG_S674 →	+1.230	+0.046	.003	.007	3	9
LSCC	RFC2 →	+0.331	+0.051	.001	<.001	3	8
GBM	RFC3 →	+0.270	+0.053	<.001	<.001	3	8
LSCC	RFC4 →	+0.392	+0.055	<.001	<.001	3	8
LUAD	SMC4 →	+0.510	+0.064	<.001	<.001	3	8
OV	MKI67_S357 →	+0.781	+0.053	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044314 vs NCAPG_S674 — OV

Explore this scatter interactively →