Protein K27-linked ubiquitination

Across TCGA pan-cancer cohorts, RNA activity of the Protein K27-linked ubiquitination pathway differs between tumor and matched normal tissue in 12 of the 18 cancer types tested.

The strongest signal is observed in lung adenocarcinoma (LUAD), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as THCA, show the opposite pattern, with lower activity in tumor tissue.

LUAD, LIHC, and THCA show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
LUAD	Female	III,IV	+0.112	<.001	9	view →
LIHC	Male	II,III,IV	+0.073	<.001	9	view →
THCA	Male	All	−0.038	<.001	9	view →
LUSC	Female	All	+0.089	<.001	8	view →
UCEC	All	II,III,IV	+0.081	<.001	8	view →
BRCA	All	III,IV	+0.063	<.001	6	view →
STAD	Male	II,III,IV	+0.053	<.001	4	view →
BLCA	All	All	+0.043	.004	4	view →
CHOL	All	All	+0.047	.002	2	view →
KIRP	All	II,III,IV	+0.029	.019	2	view →
KIRC	All	All	+0.015	.002	2	view →
HNSC	Male	II,III,IV	+0.020	.043	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 12 lineages.

GO:0044314–LUAD

Open the LUAD breakdown →