Reverse cholesterol transport

Across TCGA cell cohorts, RNA activity of the Reverse cholesterol transport pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL8A1, AKAP10, and CDKN2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COL8A1 grouped by Reverse cholesterol transport-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	COL8A1 →	-1.847	-0.891	.009	.001	3	5
LUNG_SCLC	AKAP10 →	+0.710	+1.233	.008	.004	3	4
PANCREAS	CDKN2A →	+5.175	+1.341	<.001	<.001	3	4
KIDNEY	STUB1 →	+0.588	+1.276	.003	.002	3	4
KIDNEY	CIAPIN1 →	+0.842	+1.283	<.001	<.001	3	4
KIDNEY	POLR3E →	+0.830	+1.274	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COL8A1 by Reverse cholesterol transport activity — OVARY

Explore this box plot interactively →