Recognition of apoptotic cell

Across TCGA patient cohorts, RNA activity of the Recognition of apoptotic cell pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THOC3, DYSF, and MSN_S74, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Recognition of apoptotic cell activity versus THOC3 in LSCC (Pearson r = -0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	THOC3 →	-0.374	-0.099	<.001	<.001	3	7
CCRCC	DYSF →	+0.556	+0.114	<.001	<.001	3	6
CCRCC	MSN_S74 →	+0.228	+0.069	.004	<.001	3	6
BRCA	SRRT →	-0.185	-0.044	.001	<.001	3	5
LSCC	CAMSAP3 →	-0.449	-0.072	<.001	.002	3	5
BRCA	CUL4B →	-0.206	-0.025	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043654 vs THOC3 — LSCC

Explore this scatter interactively →