Recognition of apoptotic cell

Across TCGA pan-cancer cohorts, RNA activity of the Recognition of apoptotic cell pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 7 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Recognition of apoptotic cell pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as THCA and UCS, show the opposite pattern, with higher activity associated with better survival.

MESO, READ, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.203	0.700	.002	62	view →
READ	DFS	Quartile	All	0.683	0.889	.002	47	view →
KIRP	OS	Median	All	0.599	0.762	.003	36	view →
THCA	DFS	Median	IV	0.873	0.456	.002	28	view →
STAD	OS	Quartile	III,IV	0.335	0.770	.008	27	view →
HNSC	OS	Tertile	III,IV	0.536	0.779	.003	25	view →
THYM	OS	Median	All	0.938	1.000	.010	23	view →
UCS	OS	Median	III,IV	0.733	0.421	.021	12	view →
PRAD	OS	Median	All	1.000	0.988	.026	10	view →
ACC	OS	Median	IV	0.344	0.724	.038	6	view →
LIHC	OS	Tertile	II,III,IV	0.226	0.648	.004	6	view →
KICH	DFS	Median	IV	0.317	0.923	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0043654–MESO (OS)

Open the MESO breakdown →