Positive regulation of circadian rhythm

Across TCGA patient cohorts, RNA activity of the Positive regulation of circadian rhythm pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC4, RANBP2_S3207, and SMC2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of circadian rhythm activity versus SMC4 in LUAD (Pearson r = -0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SMC4 →	-0.518	-0.075	<.001	<.001	3	7
BRCA	RANBP2_S3207 →	-0.568	-0.043	.002	.005	3	6
LUAD	SMC2 →	-0.511	-0.067	<.001	<.001	3	6
LUAD	TOP2A_S1247 →	-1.041	-0.061	.003	<.001	3	6
BRCA	EIF3H_S183 →	-0.474	-0.040	.001	.002	3	6
LUAD	KIF2C →	-0.785	-0.063	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042753 vs SMC4 — LUAD

Explore this scatter interactively →