Regulation of mesodermal cell fate specification

Across TCGA patient cohorts, RNA activity of the Regulation of mesodermal cell fate specification pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IRS2, CAMSAP2, and CAMSAP2_S599, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mesodermal cell fate specification activity versus IRS2 in HNSC (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IRS2 →	+0.531	+0.106	.001	<.001	3	5
LSCC	CAMSAP2 →	+0.189	+0.061	.006	.003	3	5
LSCC	CAMSAP2_S599 →	+0.387	+0.060	.002	.008	3	5
LUAD	BTBD8_S366 →	-1.092	-0.284	.003	.002	3	5
OV	SEC23A →	+0.388	+0.120	<.001	<.001	3	5
GBM	SFRP2 →	+1.322	+0.180	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042661 vs IRS2 — HNSC

Explore this scatter interactively →