Regulation of mesodermal cell fate specification

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of mesodermal cell fate specification pathway differs between tumor and matched normal tissue in 10 of the 18 cancer types tested.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as THCA and COAD, show the opposite pattern, with lower activity in tumor tissue.

KIRP, THCA, and COAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KIRP	Male	All	+0.115	<.001	11	view →
THCA	Female	II,III,IV	−0.140	<.001	9	view →
COAD	All	All	−0.063	<.001	9	view →
LIHC	Male	II,III,IV	+0.159	<.001	8	view →
BLCA	Male	All	−0.171	<.001	7	view →
HNSC	Male	II,III,IV	+0.065	<.001	7	view →
KIRC	Male	All	+0.051	<.001	4	view →
CHOL	All	All	+0.087	.003	3	view →
LUAD	All	III,IV	+0.071	.004	3	view →
KICH	All	II,III,IV	+0.046	.043	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 10 strongest of 10 lineages.

GO:0042661–KIRP

Open the KIRP breakdown →