Regulation of mesodermal cell fate specification

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of mesodermal cell fate specification pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher Regulation of mesodermal cell fate specification pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and LGG, show the opposite pattern, with higher activity associated with better survival.

LUAD, KIRC, and BLCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.729	0.843	<.001	132	view →
KIRC	OS	Tertile	All	0.813	0.913	<.001	68	view →
BLCA	OS	Median	III,IV	0.287	0.579	.001	45	view →
COAD	DFS	Tertile	IV	0.308	0.602	.021	28	view →
UCS	OS	Tertile	All	0.685	0.268	.007	26	view →
LGG	OS	Median	All	0.942	0.851	<.001	25	view →
THYM	OS	Tertile	II,III,IV	1.000	0.591	.001	22	view →
PAAD	OS	Median	All	0.294	0.525	.009	20	view →
HNSC	OS	Quartile	All	0.720	0.837	.004	19	view →
OV	OS	Quartile	IV	0.524	0.809	.017	18	view →
ESCA	OS	Median	II,III,IV	0.640	0.442	.011	18	view →
SCLC	DFS	Median	II,III,IV	0.262	0.762	.011	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0042661–LUAD (DFS)

Open the LUAD breakdown →