Cannabinoid signaling pathway

Across TCGA cell cohorts, RNA activity of the Cannabinoid signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNR1, GPR55, and NRCAM, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cannabinoid signaling pathway activity versus CNR1 in LUNG_SCLC (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CNR1 →	+2.238	+0.972	<.001	<.001	3	14
SKIN	GPR55 →	+1.258	+0.358	<.001	<.001	3	6
CNS	NRCAM →	+3.510	+1.229	<.001	<.001	3	6
CNS	TLR4 →	+1.409	+0.639	<.001	<.001	3	5
BLOOD_Lymphoma	ZMYND11 →	-1.224	-0.684	<.001	<.001	3	5
BLOOD_Leukemia	SERPINH1 →	-1.348	-0.551	.005	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038171 vs CNR1 — LUNG_SCLC

Explore this scatter interactively →