Cannabinoid signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Cannabinoid signaling pathway pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 9 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Cannabinoid signaling pathway pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRP and KICH, show the opposite pattern, with higher activity associated with better survival.

KIRP, KICH, and OV are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	II,III,IV	0.914	0.530	.002	109	view →
KICH	OS	Median	All	1.000	0.683	.003	42	view →
OV	DFS	Tertile	IV	0.321	0.647	.004	28	view →
UCEC	OS	Tertile	All	0.641	0.820	.001	26	view →
STAD	DFS	Median	IV	0.130	0.574	<.001	24	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	17	view →
CHOL	DFS	Tertile	All	0.730	0.100	<.001	16	view →
MESO	DFS	Quartile	IV	0.139	0.513	.027	15	view →
LUSC	DFS	Tertile	All	0.281	0.469	.011	13	view →
READ	DFS	Tertile	III,IV	0.766	0.358	.007	13	view →
THCA	OS	Median	II,III,IV	1.000	0.637	.009	12	view →
LAML	DFS	Quartile	All	0.342	0.669	.013	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0038171–KIRP (DFS)

Open the KIRP breakdown →