Interleukin-11-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interleukin-11-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR37, MCM7, and MCM2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-11-mediated signaling pathway activity versus WDR37 in UCEC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WDR37 →	+0.210	+0.047	<.001	.005	3	7
LUAD	MCM7 →	-0.616	-0.088	<.001	<.001	3	7
LUAD	MCM2 →	-0.620	-0.083	<.001	<.001	3	7
CCRCC	SPTBN2 →	-0.436	-0.053	.001	.001	3	6
LSCC	RRM1 →	-0.587	-0.083	<.001	.001	3	6
LUAD	RRM2 →	-0.494	-0.084	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038154 vs WDR37 — UCEC

Explore this scatter interactively →