Q-omics provides the consensus-scored IL11 profile across patient tissues and cancer cell-line models. IL11 expression is associated with patient survival in 29 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, IL11 is differentially expressed in 17, with the highest sampling consensus in HNSC. Additionally, IL11 RNA expression shows 15,743 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRC, HNSC, and UVM as cancer lineages where IL11 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for IL11 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes IL11 survival associations across molecular data types. IL11 RNA expression shows survival associations in the most cancer types (29), followed by mutation status (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible IL11 RNA expression–survival associations across cancer types. High IL11 expression shows unfavorable associations in KIRC, MESO, ACC, KIRP, UVM and LUSC. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for IL11 RNA expression.
This table summarizes IL11 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 17. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for IL11. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. IL11 shows lower tumor expression in KIRC and KICH and higher tumor expression in HNSC, COAD, STAD and LUAD. The HNSC box plot shows higher IL11 RNA expression in tumor versus normal tissue (log2 FC = +3.170, t-test p < 0.001).
This table shows molecular features associated with IL11 in patient tissues and cancer cell lines. In patient samples, IL11 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, IL11 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Myeloma, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and BONE.
