IL11

Across TCGA patient cohorts, IL11 mutation is significantly associated with the RNA expression of many other genes, with 78 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IL11-associated genes across cancer lineages are RNU6-1036P, MIR6128, and H2AB3. Each is linked with IL11 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL11-to-partner and partner-to-IL11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1036P grouped by IL11-low versus IL11-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL11→partner) and Y-score (partner→IL11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-1036P →	+0.421	+3.781	.001	.001	3	2
BRCA	MIR6128 →	+0.743	+8.471	<.001	.005	3	1
SKCM	H2AB3 →	+0.095	+7.816	<.001	<.001	3	1
SKCM	MIR6076 →	+0.508	+4.730	<.001	.003	3	1
SKCM	KRTAP4-17P →	+0.181	+4.867	<.001	.005	3	1
SKCM	RNU6-752P →	+0.374	+5.797	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

RNU6-1036P by IL11 expression — COAD

Explore this box plot interactively →