IL11

Across TCGA cell cohorts, IL11 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,742 significant associations in total. BONE shows the largest number of these associations.

The most reproducible IL11-associated GO terms across cancer lineages are Dentinogenesis, Regulation of plasminogen activation, and Proteinogenic amino acid metabolic process. Each is linked with IL11 in more than 13 cancer types. Because this analysis shows association rather than direction, both IL11-to-partner and partner-to-IL11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dentinogenesis grouped by IL11-low versus IL11-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IL11→partner) and Y-score (partner→IL11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Dentinogenesis →	+1.839	+2.958	<.001	<.001	3	14
CNS	Regulation of plasminogen activation →	+0.277	+2.657	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Proteinogenic amino acid metabolic process →	-0.099	-1.828	.002	.003	3	12
LIVER	Positive regulation of extracellular matrix organization →	+0.202	+3.764	.001	.003	3	12
STOMACH	Regulation of protein localization to mitochondrion →	+0.124	+2.058	<.001	<.001	3	12
SKIN	Urokinase plasminogen activator signaling pathway →	+0.693	+1.671	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,742 associations by consensus.

Dentinogenesis by IL11 expression — BONE

Explore this box plot interactively →