Interleukin-11-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Interleukin-11-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UCHL3, EXT2, and PLOD1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-11-mediated signaling pathway activity versus UCHL3 in LUNG_SCLC (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	UCHL3 →	+1.082	+0.349	.002	<.001	3	3
SKIN	EXT2 →	+0.945	+0.312	.002	.008	3	3
SKIN	PLOD1 →	+1.605	+0.312	.006	.008	3	3
PANCREAS	IL1A →	+3.852	+1.732	<.001	.007	3	2
PANCREAS	JUND →	-1.582	-1.687	.009	.008	3	2
PANCREAS	AFAP1L1 →	+2.735	+1.701	.002	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038154 vs UCHL3 — LUNG_SCLC

Explore this scatter interactively →