Platelet-derived growth factor receptor-beta signaling pathway

Across TCGA cell cohorts, RNA activity of the Platelet-derived growth factor receptor-beta signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBBP7, ADAM19, and ZNF687, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Platelet-derived growth factor receptor-beta signaling pathway activity versus RBBP7 in STOMACH (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RBBP7 →	+1.130	+1.834	.006	<.001	3	3
STOMACH	ADAM19 →	+2.373	+1.388	.001	.005	3	3
BREAST	ZNF687 →	-1.097	-1.343	.001	.001	3	3
STOMACH	DEGS1 →	+1.919	+1.388	.005	.005	2	4
STOMACH	ITGB1 →	+2.116	+1.884	<.001	<.001	3	3
STOMACH	CACNB3 →	-3.150	-1.770	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035791 vs RBBP7 — STOMACH

Explore this scatter interactively →