Platelet-derived growth factor receptor-beta signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Platelet-derived growth factor receptor-beta signaling pathway pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 14 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Platelet-derived growth factor receptor-beta signaling pathway pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and CHOL, show the opposite pattern, with higher activity associated with better survival.

UVM, STAD, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	III,IV	0.427	0.889	<.001	91	view →
STAD	DFS	Median	II,III,IV	0.217	0.464	.001	71	view →
MESO	OS	Tertile	II,III,IV	0.184	0.447	.002	66	view →
UCEC	OS	Median	All	0.832	0.907	.001	64	view →
LGG	DFS	Median	All	0.781	0.871	<.001	44	view →
KIRP	DFS	Median	All	0.603	0.901	.003	44	view →
BLCA	OS	Quartile	All	0.514	0.693	.004	43	view →
BRCA	DFS	Median	III,IV	0.577	0.411	.004	39	view →
KIRC	OS	Median	All	0.547	0.695	<.001	36	view →
LIHC	DFS	Median	All	0.408	0.626	.003	30	view →
CESC	DFS	Median	All	0.747	0.877	<.001	28	view →
THCA	DFS	Tertile	II,III,IV	0.595	0.872	.009	27	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0035791–UVM (OS)

Open the UVM breakdown →