Vitamin transmembrane transport

Across TCGA patient cohorts, RNA activity of the Vitamin transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MISP3_S91, CYP27A1, and AS3MT, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin transmembrane transport activity versus MISP3_S91 in BRCA (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MISP3_S91 →	+1.119	+0.068	<.001	<.001	3	5
LSCC	CYP27A1 →	+0.425	+0.046	<.001	<.001	3	5
BRCA	AS3MT →	+0.399	+0.038	.002	<.001	3	5
BRCA	GOLPH3L_S23 →	+0.437	+0.031	.002	.003	2	6
LSCC	SH3BGRL2 →	+0.241	+0.041	.005	<.001	3	5
LUAD	LRP2 →	+0.519	+0.038	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035461 vs MISP3_S91 — BRCA

Explore this scatter interactively →