Vitamin transmembrane transport

Across TCGA pan-cancer cohorts, RNA activity of the Vitamin transmembrane transport pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 21 member genes.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher Vitamin transmembrane transport pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUAD and PAAD, show the opposite pattern, with higher activity associated with better survival.

LUAD, COAD, and PAAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.325	0.161	<.001	59	view →
COAD	OS	Quartile	All	0.454	0.759	.001	48	view →
PAAD	OS	Tertile	II,III,IV	0.668	0.392	.008	48	view →
UVM	DFS	Median	All	0.460	0.696	.002	38	view →
CESC	DFS	Tertile	All	0.634	0.836	<.001	36	view →
THCA	OS	Tertile	II,III,IV	0.887	0.976	.007	30	view →
ACC	DFS	Median	All	0.276	0.647	.001	29	view →
LAML	DFS	Tertile	All	0.536	0.281	.003	26	view →
KIRP	OS	Tertile	II,III,IV	0.776	0.173	.003	26	view →
BRCA	OS	Tertile	III,IV	0.962	0.862	.004	25	view →
LGG	DFS	Tertile	All	0.758	0.864	<.001	24	view →
KIRC	DFS	Median	II,III,IV	0.612	0.470	.013	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0035461–LUAD (OS)

Open the LUAD breakdown →