Vitamin transmembrane transport

Across TCGA patient cohorts, RNA activity of the Vitamin transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRP2, CYP4V2, and NPM1P11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin transmembrane transport activity versus LRP2 in LUAD (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LRP2 →	+2.148	+0.712	<.001	<.001	3	4
CCRCC	CYP4V2 →	+0.706	+0.282	.001	.006	3	4
LSCC	NPM1P11 →	-0.534	-0.407	.006	.004	3	3
LSCC	PBOV1 →	+0.562	+0.296	.003	.006	2	4
BRCA	LGALS1 →	-1.021	-0.521	<.001	.008	2	4
CCRCC	ST3GAL4 →	-0.235	-0.223	.008	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035461 vs LRP2 — LUAD

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