Q-omics provides the consensus-scored NPM1P11 profile across patient tissues and cancer cell-line models. NPM1P11 expression is associated with patient survival in 11 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, NPM1P11 is differentially expressed in 4, with the highest sampling consensus in THCA. Additionally, NPM1P11 RNA expression shows 11,202 significant protein co-abundance associations, with the highest sampling consensus in PDAC. Together, these results highlight KIRC, THCA, and PDAC as cancer lineages where NPM1P11 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for NPM1P11 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes NPM1P11 survival associations across molecular data types. NPM1P11 RNA expression shows survival associations in the most cancer types (11). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible NPM1P11 RNA expression–survival associations across cancer types. High NPM1P11 expression shows unfavorable associations in KIRC, ACC, BRCA, UVM and HNSC, but favorable associations in LUAD. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for NPM1P11 RNA expression.
This table summarizes NPM1P11 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for NPM1P11. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. NPM1P11 shows lower tumor expression in THCA and higher tumor expression in LUAD, COAD and LUSC. The THCA box plot shows higher NPM1P11 RNA expression in normal versus tumor tissue (log2 FC = −0.045, t-test p = .005).
This table shows molecular features associated with NPM1P11 in patient tissues and cancer cell lines. In patient samples, NPM1P11 shows the broadest associations at the RNA and protein expression levels, with PDAC recurring as the lineage with the largest associated feature set.
