Across TCGA pan-cancer cohorts, NPM1P11 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of NPM1P11’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NPM1P11 RNA is repressed in tumor relative to normal tissue. In most cancer types NPM1P11 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA, LUAD, and COAD are the cancer types where NPM1P11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPM1P11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.045	.005	2	view →
LUAD	All	All	+0.099	.045	1	view →
COAD	All	All	+0.030	.038	1	view →
LUSC	All	All	+0.017	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: NPM1P11 RNA expression & survival · all NPM1P11 data types