Vitamin transmembrane transport

Across TCGA cell cohorts, RNA activity of the Vitamin transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCARB1, RALY, and UQCRC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin transmembrane transport activity versus SCARB1 in SKIN (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SCARB1 →	+2.151	+1.544	.002	<.001	3	5
BLOOD_Lymphoma	RALY →	-0.651	-0.869	.003	.005	3	4
OVARY	UQCRC2 →	+0.915	+1.690	<.001	<.001	3	4
LUNG_NSCLC_LUAD	C4orf3 →	-1.144	-1.135	.002	.003	3	4
LUNG_NSCLC_LUSC	ZCCHC4 →	-0.592	-1.541	.004	.006	3	4
BLOOD_Lymphoma	TCF19 →	-1.483	-0.993	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035461 vs SCARB1 — SKIN

Explore this scatter interactively →