Regulation of peroxisome proliferator activated receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of peroxisome proliferator activated receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ST6GALNAC4, MIR4539, and KCNS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of peroxisome proliferator activated receptor signaling pathway activity versus ST6GALNAC4 in HNSC (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ST6GALNAC4 →	+0.537	+0.492	.007	.004	3	4
HNSC	MIR4539 →	+1.558	+0.621	<.001	<.001	3	4
COAD	KCNS2 →	+0.064	+0.651	<.001	<.001	3	3
OV	CICP28 →	+0.064	+0.647	.005	<.001	3	3
LSCC	CHRDL2 →	+0.286	+0.420	.001	.004	3	3
PDAC	P2RX1 →	+0.677	+0.290	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035358 vs ST6GALNAC4 — HNSC

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