Q-omics provides the consensus-scored MIR4539 profile across patient tissues and cancer cell-line models. MIR4539 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, MIR4539 is differentially expressed in 4, with the highest sampling consensus in HNSC. Additionally, MIR4539 RNA expression shows 11,024 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight HNSC, and LSCC as cancer lineages where MIR4539 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MIR4539 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MIR4539 survival associations across molecular data types. MIR4539 RNA expression shows survival associations in the most cancer types (21). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MIR4539 RNA expression–survival associations across cancer types. High MIR4539 expression shows unfavorable associations in KIRC and LGG, but favorable associations in HNSC, BLCA, SKCM and ESCA. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for MIR4539 RNA expression.
This table summarizes MIR4539 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for MIR4539. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MIR4539 shows lower tumor expression in THCA and higher tumor expression in HNSC, LUAD and KIRC. The HNSC box plot shows higher MIR4539 RNA expression in tumor versus normal tissue (log2 FC = +0.467, t-test p = .003).
This table shows molecular features associated with MIR4539 in patient tissues and cancer cell lines. In patient samples, MIR4539 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set.
