MIR4539

Across TCGA pan-cancer cohorts, MIR4539 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated MIR4539 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MIR4539 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MIR4539 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

HNSC, BLCA, and SKCM are the cancer types where MIR4539 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	II,III,IV	0.796	0.644	<.001	111	view →
BLCA	DFS	Tertile	All	0.710	0.574	.001	78	view →
SKCM	OS	Median	All	0.394	0.288	<.001	74	view →
ESCA	DFS	Quartile	II,III,IV	0.646	0.424	.009	43	view →
KIRC	OS	Tertile	All	0.539	0.676	.002	41	view →
LGG	DFS	Tertile	All	0.341	0.748	<.001	39	view →
LUAD	DFS	Tertile	III,IV	0.831	0.458	.002	38	view →
UVM	DFS	Tertile	All	0.241	0.771	.004	27	view →
STAD	OS	Median	II,III,IV	0.692	0.410	.012	19	view →
LIHC	DFS	Tertile	All	0.495	0.234	.007	18	view →
LAML	DFS	Quartile	All	0.246	0.575	.006	18	view →
CESC	OS	Quartile	IV	0.808	0.219	.014	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

MIR4539–HNSC (DFS)

Open the HNSC breakdown →