MIR4539

Across TCGA pan-cancer cohorts, MIR4539 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MIR4539’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MIR4539 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR4539 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, LUAD, and KIRC are the cancer types where MIR4539 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR4539 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.467	.003	7	view →
LUAD	All	All	+0.911	<.001	5	view →
KIRC	All	All	+0.349	.001	5	view →
THCA	All	All	−0.529	.038	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

MIR4539–HNSC

Open the HNSC breakdown →