Behavioral response to nicotine

Across TCGA cell cohorts, RNA activity of the Behavioral response to nicotine pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUMO2, TLE3, and RPS27A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SUMO2 grouped by Behavioral response to nicotine-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SUMO2 →	-0.602	-1.409	.009	.008	2	6
BREAST	TLE3 →	-1.545	-0.968	<.001	.001	3	4
OESOPHAGUS	RPS27A →	+0.617	+0.482	<.001	.005	3	4
BONE	NUTM2D →	-0.809	-1.835	.001	<.001	3	4
BREAST	ZFHX2 →	-0.694	-1.162	.003	.001	3	3
BLOOD_Myeloma	SIX1 →	+2.857	+2.123	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SUMO2 by Behavioral response to nicotine activity — URINARY_TRACT

Explore this box plot interactively →