Behavioral response to nicotine

Across TCGA pan-cancer cohorts, RNA activity of the Behavioral response to nicotine pathway differs between tumor and matched normal tissue in 9 of the 18 cancer types tested.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as LIHC and CHOL, show the opposite pattern, with lower activity in tumor tissue.

KIRC, LIHC, and THCA show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KIRC	All	III,IV	+0.080	<.001	9	view →
LIHC	Female	II,III,IV	−0.163	<.001	8	view →
THCA	All	All	+0.056	<.001	6	view →
CHOL	Male	All	−0.323	<.001	5	view →
LUAD	Male	All	+0.073	<.001	4	view →
COAD	Male	III,IV	+0.061	.001	4	view →
LUSC	Male	All	+0.051	.001	4	view →
COAD	Female	IV	−0.074	.021	1	view →
STAD	Male	IV	+0.070	.019	1	view →
HNSC	Female	All	+0.044	.031	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 10 strongest of 9 lineages.

GO:0035095–KIRC

Open the KIRC breakdown →