Low-density lipoprotein particle clearance

Across TCGA patient cohorts, RNA activity of the Low-density lipoprotein particle clearance pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WIPF1, KCTD12, and MRC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Low-density lipoprotein particle clearance activity versus WIPF1 in GBM (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	WIPF1 →	+0.265	+0.054	<.001	<.001	3	6
GBM	KCTD12 →	+0.464	+0.061	<.001	<.001	3	6
GBM	MRC1 →	+0.632	+0.053	<.001	<.001	3	6
GBM	DAB2 →	+0.558	+0.056	<.001	<.001	3	6
BRCA	C17orf75 →	-0.279	-0.044	.004	.002	3	6
OV	TARS2 →	-0.367	-0.041	.006	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034383 vs WIPF1 — GBM

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