Low-density lipoprotein particle clearance

Across TCGA cell cohorts, RNA activity of the Low-density lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCEH1, FOSL1, and RASGRP3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Low-density lipoprotein particle clearance activity versus NCEH1 in BONE (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	NCEH1 →	+2.858	+1.985	.004	<.001	3	6
BONE	FOSL1 →	+5.180	+2.006	.001	<.001	3	6
BREAST	RASGRP3 →	+0.824	+1.307	<.001	<.001	3	6
STOMACH	POLR3B →	-0.923	-1.336	.004	.006	3	5
BONE	HEXB →	+2.592	+2.049	.001	<.001	3	5
BREAST	IKBIP →	+1.287	+0.934	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034383 vs NCEH1 — BONE

Explore this scatter interactively →